Abstract
ObjectiveThe relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. The associations among metabolic syndrome (MetS), serum uric acid and CKD are also unclear. We aimed to investigate the relationship between decreased BMD, MetS, serum uric acid and CKD in a general population.MethodsA total of 802 subjects who visited a medical center in Southern Taiwan and underwent a BMD measured by dual-energy X-ray absorptiometry (DEXA) during a health examination were enrolled in this retrospective cross-sectional study. Either osteopenia or osteoporosis was defined as decreased BMD. CKD was defined as the estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73m2. Simple and multivariate logistic regression analyses were used to investigate the association between variables, decreased BMD and CKD.ResultsOf the 802 subjects with a mean age of 54.4±10.2 years, the prevalence of decreased BMD was 62.9%, and CKD was 3.7%. Simple logistic analysis showed that sex (OR 3.50, 95% CI 1.21–10.12, p = 0.021), age (OR 1.14, 95% CI 1.07–1.21, p<0.001), BMI (OR 1.11, 95% CI 1.01–1.22, p = 0.028), waist circumference (OR 1.06, 95% CI 1.02–1.10, p = 0.002), SBP (OR 1.03, 95% CI 1.01–1.04, p = 0.003), DBP (OR 1.03, 95% CI 1.00–1.06, p = 0.030), HDL-C (OR 0.97, 95% CI 0.94–1.00, p = 0.026), uric acid (OR 1.84, 95% CI 1.49–2.27, p<0.001), metabolic syndrome (OR 2.68, 95% CI 1.29–5.67, p = 0.009), and decreased BMD (OR 3.998, 95% CI 1.38–11.57, p = 0.011) were significantly associated with CKD. Multivariate analysis showed that age (OR 1.05, 95% CI 1.03–1.07, p<0.001), decreased BMD (OR 0.64, 95% CI 0.45–0.91, p = 0.013), and uric acid (OR 1.40, 95% CI 1.24–1.59, p<0.001) were significantly independently associated with CKD.ConclusionsDecreased BMD, uric acid and MetS were significantly associated with CKD.. Further large and prospective cohort studies are necessary to investigate whether management of osteoporosis, hyperuricemia, or MetS might prevent the progression of CKD.
Highlights
Chronic kidney disease (CKD) is a global health problem and increasing worldwide
A total of 802 subjects who visited a medical center in Southern Taiwan and underwent a bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DEXA) during a health examination were enrolled in this retrospective cross-sectional study
Simple logistic analysis showed that sex, age, Body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), uric acid, metabolic syndrome, and decreased BMD were significantly associated with CKD
Summary
Chronic kidney disease (CKD) is a global health problem and increasing worldwide. The prevalence of CKD in Taiwan was 9.8–11.9% and 13.1% in the United States by National Health and Nutrition Examination Survey (NHANES III, 1999–2004) [1, 2]. Endstage renal disease (ESRD) is significantly associated with decreased BMD and osteoporosis [3]; the relationship between decreased BMD and CKD is controversial. From the Third National Health Assessment and Nutritional Examination Survey (NHANES III) data, there was no significant relationship of decreased BMD and CKD after adjustment for age, sex and race [5]. The Kidney Disease: Improving Global Outcomes (KDIGO) publication suggests BMD testing can play a role in screening among the population with stages 3–5 CKD [6]. Several studies have revealed the association of renal function and BMD in Asian countries [7, 8], but there is a lack of such studies performed in Taiwan
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
