Abstract
Abstract Background: Peripheral neuropathy is known to be related to inflammatory bowel disease and it is one of the most frequently reported neurologic complications. Various studies have found peripheral nervous system complications, rather than central nervous system involvement, to be predominant. In the literature, there are a few cases of inflammatory polyneuropathy developed in the course of ulcerative colitis : 5 cases of Guillain-Barre syndrome, one case of chronic inflammatory demyelinating polyneuropathy, 10 cases of neuropathy and one case of perineuritis. Case presentation: We describe a case of chronic inflammatory polyneuropathy associated with ulcerative colitis. Conclusion: Peripheral neuropathy is not a common manifestation of IBD, highlighting the need for careful exclusion of other causes of neuropathy when both conditions are encountered in clinical practice.
Highlights
Peripheral neuropathy is known to be related to inflammatory bowel disease and it is one of the most frequently reported neurologic complications
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with various extra-intestinal manifestations and there are a few reports of neurologic involvement in this setting without previous medication (Table 2)
In 1985, 2 elderly patients with Guillain-Barré syndrome (GBS) were reported while the UC was in remission [1]
Summary
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD) showing immunologic abnormalities and associated with autoimmune states. Examination revealed a marked weakness of both legs and mild weakness of her arms (MRC grade 2 in lower limbs and grade 4 in upper limbs). The patient was treated with IVG, 400 mg/kg/ day, five days, with no improvement of symptoms. Two weeks afterwards she developed intense rec-. A sigmoidectomy was performed because the sigmoid colon was the most affected by colitis, which brought the patient to her normal control of intestinal symptoms. Azathioprine 2 mg/kg daily was added and patients neurological condition continued to improve for 3 years and after that the patient never returned
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