Dynamics of the incidence of acute and chronic inflammatory polyneuropathies in adults in the Leningrad region

E A Skornyakova,L G Zaslavskii

doi:10.17650/2222-8721-2021-11-1-39-46

Abstract

Background. Inflammatory polyneuropathies (IPNP) are diseases caused by an immune response against antigens in the peripheral nervous system. Epidemiological research is essential for health resource planning.Objective: to assess the clinical and epidemiological characteristics of acute and chronic IPNP in adults in the Leningrad region.Materials and methods. We analyzed the incidence of acute and chronic IPNP the Leningrad region for the last 24 years.Results. A gradual increase in the incidence rate since 2003 with slight fluctuations has been shown. A particularly significant increase was recorded in 2015 from 14 (2014) to 22 patients, while in previous years fluctuations ranged from 4 to 10 people. In 2016 and 2017, the number of cases increased even more to 26–27 per year (there are 1 600 000 residents over 18 years of age in the region). At the same time, an increase in the incidence of both Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) was noted. The incidence of GBS in the last 10 years was 0.18–0.88, the incidence of CIDP was the same 0.18–1.0 per 100 000 population. With GBS, women were more likely to get sick, with CIDP – men. With GBS, the debut was more often in winter (35 %), in summer and autumn, 25 % each, less often in spring – 17 %. The average age of GBS development in our study was 50.3 years. CIDP also fell ill at all age periods from 19 to 84 years (average age 55.6 years). The most common GBS triggers were acute respiratory viral infections in 36 % and enterocolitis in 13 %. Respiratory disorders requiring mechanical ventilation were observed in 8 % of patients with GBS.Conclusions. The incidence of IPNP in adults, both acute and chronic in the Leningrad region, is growing with some fluctuations. This should be taken into account for health resource planning.

Highlights

Проанализирована заболеваемость острыми и хроническими Воспалительные полиневропатии (ВПНП) в Ленинградской области за последние 24 года
Inflammatory polyneuropathies (IPNP) are diseases caused by an immune response against antigens in the peripheral nervous system
The incidence of Guil‐ lain–Barré syndrome (GBS) in the last 10 years was 0.18–0.88, the incidence of chronic inflammatory demyelinating polyneuropathy (CIDP) was the same 0.18–1.0 per 100 000 population

Summary

Оригинальные исследования

ГБУЗ Ленинградская областная клиническая больница; Россия, 194291 Санкт-Петербург, пр-т Луначарского, 45–49. Эпидемиологические исследования важны для планирования ресурсов здравоохранения. Цель исследования – оценка клинических и эпидемиологических характеристик острой и хронической ВПНП у взрослых в Ленинградской области. Проанализирована заболеваемость острыми и хроническими ВПНП в Ленинградской области за последние 24 года. При этом отмечен рост заболеваемости как син‐ дромом Гийена–Барре (СГБ), так и хронической воспалительной демиелинизирующей полиневропатией (ХВДП). Заболеваемость СГБ в последние 10 лет составляла 0,18–0,88, заболеваемость ХВДП – 0,18–1,0 на 100 000 населения. При СГБ несколько чаще заболевали женщины, при ХВДП – мужчины. ХВДП заболевали также во все возрастные периоды – от 19 до 84 лет (средний возраст – 55,6 года). Заболеваемость ВПНП – как острыми, так и хроническими – у взрослых в Ленинградской области растет с некоторыми колебаниями. Г. Динамика заболеваемости острой и хронической вос‐ палительными полиневропатиями у взрослых в Ленинградской области. Zaslavskii Leningrad Regional Clinical Hospital; 45–49 Lunacharskogo Prospekt, Saint Petersburg 194291, Russia

Background

Results

Всего In total