Abstract
Colorectal cancer (CRC) is the third common cancer and fourth cancer related mortality, worldwide. Chronic Inflammation is one of the underlying mechanisms leads to this cancer. The final aim of this research was to assess the expression level of pattern recognition receptor (PRRs)-related genes TLR2, TLR4, NLRP3, NF-kβ, MBL1, GAL1 and oxidative agent NOS2 in colon tissue and blood monocytes of CRC patients to find the relative role of chronic inflammation in the initiation of the stage II CRC development. by this approach, the expression level of mentioned genes was assessed in colon tissues and monocytes of 24 cases (12 CRC and 12 healthy control persons) by 65±11 years old men. In CRC patients’ monocytes, the expression level of TLR2, TLR4, GAL1 and MBL1 genes were significantly less than those of healthy controls (p<0.05). the expression level of NOS2 and NF-kβ genes in CRC patients’ monocytes was significantly higher than those of in healthy controls (p<0.05).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
