Abstract
BackgroundHepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan.MethodsPatients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) for determining the association between CHI and cancer development.ResultsThe patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 % CI: 1.09–1.70), liver cancer (HR: 21.47, 95 % CI: 18.0–25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 % CI: 1.07–3.91), pancreatic cancer (HR: 2.61, 95 % CI: 1.47–4.61), kidney cancer (HR: 1.72, 95 % CI: 1.10–2.68), ovarian cancer (HR: 2.31, 95 % CI: 1.21–4.39), and non-Hodgkin’s lymphoma (HR: 2.10, 95 % CI: 1.25–3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 % CI: 20.9–30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 % CI: 1.42–4.73), ovarian cancer (HR: 5.15, 95 % CI: 1.98–13.4), and non-Hodgkin’s lymphoma (HR: 2.30, 95 % CI: 1.34–3.96).ConclusionThe present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.
Highlights
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI)
2 billion people worldwide have been infected with HBV, and 360 million people are currently chronic carriers [1]
Some studies have revealed an association between CHI and the development of extrahepatic cancers such as pancreatic cancer [10], gallbladder and extrahepatic bile duct cancer [11], intrahepatic cholangiocarcinoma, and non-Hodgkin’s lymphoma [12,13,14,15]
Summary
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI) This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. 2 billion people worldwide have been infected with HBV, and 360 million people are currently chronic carriers [1]. HCV has been estimated to infect approximately 185 million people worldwide, with the highest prevalence in Central and East Asian, North African, and Middle Eastern regions [2], and more than. A study in Kamiza et al BMC Cancer (2016) 16:861
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