Abstract
This review overlooks the current international, and national status of chronic hepatitis C. Presence of antiHCV antibodies is used as a marker for chronic hepatitis C. With the help of molecular biology techniques, seven major HCV genotypes were identified worldwide. In addition, the latest genome sequencing techniques (SBT, NextGeneration Sequencing) analyzed the relationship between the HLA genes and KIR genes with chronic hepatitis C. Three HLA alleles (HLA A*23:01, B*44:02, and C*04:02) and four KIR genes (KIR2DL3, KIR2DL5, KIR2DS4, and KIR3DL3) have been associated with the chronic HCV infection in Romania and worldwide.
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