Chronic Hepatitis C Prevalence and its Correlation with CD4 Cells and Liver Enzymes Among HIV Positive Patients: A Malaysian Scenario.

Abstract

PIN5 ChroNIC hePatItIs C PrevaleNCe aNd Its CorrelatIoN wIth Cd4 Cells aNd lIver eNzymes amoNg hIv PosItIve PatIeNts: a malaysIaN sCeNarIo Khan A.H.1, Sulaiman S.A.2, Soo C.T.3, Akhtar A.1, Hamzah D.A.B.A.4, Khan K1 1Universiti Sains Malaysia, Minden, Malaysia, 2Universiti Sains Malaysia, Penang, Malaysia, 3medical department Penang hospital, penang, Minden, Malaysia, 4Urology Unit, Department of Surgery, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia, Kelantan Malaysia, Malaysia Objectives: To evaluate the occurrence and clinical outcomes of Hepatitis C (HCV) patients co-infected with Human Immunodeficiency Syndrome (HIV) in a tertiary care hospital. MethOds: A retrospective study of the patients with clinical histories of HIV co-infection with HCV following HAART therapy in Infectious disease Unit at Hospital Palau Pinang (HPP), Malaysia from the year 2007 to 2012. The clinical and demographic data was collected from patient’s records. In present study we analyzed the collected data by using SPSS software (Version 20) to determine the correlation of variables and measure their infection rates in a particular population. Results: The study involves a total of 708 HIV infected patients with the mean age of 40 ± 10.17 years together with 541(76.4%) males and 167(23.6%) females. There were 130(18.4%) patients co-infected with HCV. The assigned population involve in current study was Chinese 427(60.3%) followed by Indians 96(13.6%), Malay 151(21.3%) and minorities 34 (4.8%). There were three main modes of transmission including male heterosexual contact 506(71.5%), homosexual contact 47(6.6%) and intravenous drug users (IVDU) 114(16.1%). The mean CD4 count, ALT and AST levels in HBV-HIV co-infected patients were 374 ± 150.65, 64 ± 76.15, 129 ± 61.06 respectively. The calculated result shows the significant association of several factors like sex (p = < 0.001), IVDU (p = < 0.001) with co-infection of HIV-HCV. The co-morbidities observed in the current study were Pulmonary Tuberculosis (23.6%), Pneumocystis pneumonia (14.4%), Hyperlipidemia (4.4%), Dyslipidemia (3.2%), Anemia (4.5%), Ischemic Heart Disease (2.5%), Diabetes Mellitus (8.2%), Hypertension (6.5%), Asthma (1.4%), Oral Candiasis (5.2%), Syphillus (3.1%), Liver Cirrohsis (1.1%), Cerebral Toxoplasmosis (2.3%), Virological Failure (1.1%). cOnclusiOns: The incidence rate of HCV among HIV individuals were about 18.4% including 76.4% males and 23.6% females. There was a significant correlation between HCV among HIV-positive patients depending on various variables like gender, age, exposure to risk factors. (p< 0.001).