Abstract
Investigations were performed in the rat to examine the effects of prolonged administration of aspirin on the gastric mucosa. Groups of rats received aspirin by esophageal intubation in doses of 120, 250, or 500 mg per kg per day for 6 months. Chronic gastric ulcers were found in the antral mucosa in 9 of 16 rats given 250 or 500 mg per kg per day of aspirin. In addition, there were multiple erosions in the glandular mucosa in all of the aspirin-treated rats surviving the treatment period. In a control group, gastric histology was normal in every instance. Mucosal recovery was virtually complete in rats in the 120 and 250 mg per kg groups allowed to survive for an additional 3 weeks, without aspirin; but in the 250 mg per kg group, some healed chronic ulcers were identified. Despite the extensive morphological damage at the end of treatment, the only observed biochemical change was an increase in sialic acid output in the 250 mg per kg group. The investigation has established a model of aspirin-induced chronic gastric ulcer. The model may have a clinical counterpart in the chronic gastric ulcers which develop in association with habitual ingestion of aspirin-containing preparations.
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