Abstract
Histological and radio-autographic studies with tritiated thymidine were performed on the gastric mucosa of rats following aspirin administration by oesophageal intubation. Following single doses of aspirin, multiple acute erosions were present in the fundic mucosa of all rats. After repeated doses, 3 types of lesions were observed: acute, re-epithelialized and chronic erosions. Administration of daily aspirin for 6 mth resulted in chronic gastric ulcers and atypical proliferatlon of gastric mucosal glands. This experimental model may have a clinical counterpart in patients with habitual ingestion of aspirin and chronic gastric ulcer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.