Abstract
The benzodiazepine partial agonist Rol6-6028 does not lead to GABA A receptor downregulation in vivo. To assess effects of this compound in vitro, cultured neurons were exposed to Rol6-6028, 1 and 10 μM. GABA-dependent chloride uptake was unaffected at either dose of Rol6-6028 from 2 to 10 days, in contrast to decreased function observed with clonazepam, 1 μM, at 10 days. Ro16-6028 exposure did not alter GABA-independent chloride uptake, total neuronal protein, or cellular protein synthesis.
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