Abstract

Introduction: Bisphenol A (BPA) is an endocrine disrupting chemical, therefore some countries have banned the use of it in plastic containers for food storage and plastic toys for children. BPA can be found in natural waters with measured concentrations varying from ng/l to mg/l. However, in fact that the chronic ecotoxicology data obtained from aquatic animals for BPA exposure at these levels are quite few.
 Methods: In this study zebrafish at 30 days of age were exposed to four variants 0, 1, 10 and 100 μg/l BPA along 60 days, which is the fasted growth period in zebrafish (Juvenile stage). At the end of the experiments, all fish weight and length were measured and their fresh livers were used for histological assessment.
 Results: The results showed that weight and length of fish in 100 mg/l BPA group increased significantly as compared with that in the other experimental groups. Also only in this group, changes in hepatic morphology such as vacuolar number and size increasement, cytoplasmicand/or nuclear enlargement, glycogen reduction, lipid enhancement, were observed, but especially no significant inflammation. Fish in the other groups exposed to BPA concentrations <100mg/l had no change in all targeted endpoints as compared with that of the control.
 Conclusion: Chronic exposure of 100mg/L BPA to zebrafish along the fast-growth period (Juvenile) caused increasement of weight and length, and altered morphology of hepatic cells, that may harm to liver functions.

Highlights

  • Bisphenol A (BPA) is an endocrine disrupting chemical, some countries have banned the use of it in plastic containers for food storage and plastic toys for children

  • Hình 2: Tiêu bản nhuộm PAS tế bào gan cá sau phơi nhiễm với 100 μg/L BPA

  • Các thí nghiệm với cá sọc ngựa ở nghiên cứu này thuộc đề tài C2017-20-35 của Đại học Quốc gia TP.HCM

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Summary

Bài nghiên cứu

Ảnh hưởng mãn tính của phơi nhiễm Bisphenol A lên cá sọc ngựa (Danio rerio) ở giai đoạn Juvenile. Ngô Thị Mai[1], Đoàn Thị Phương Thảo[2], Võ Thị Ngọc Diễm[2], Nguyễn Thành Công[3], Lê Phi Nga4,*

TÓM TẮT
GIỚI THIỆU
Đối tượng và nguyên vật liệu
Phân tích mô bệnh học gan cá
Đánh giá điều kiện phơi nhiễm mãn tính
Ảnh hưởng của BPA lên sự tăng trưởng
Ảnh hưởng của BPA lên hình thái mô gan
THẢO LUẬN
Kiềm hoá bào tương
KẾT LUẬN
DANH MỤC TỪ VIẾT TẮT
TÀI LIỆU THAM KHẢO
Full Text
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