Abstract
1. 1. The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of such an association on rat pregnancy. 2. 2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the Ist to the 20th day of gestation. 3. 3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT + ACV and was virtually absent with AZT alone. 4. 4. The abortive action of ACV was markedly diminished in the group treated with the association AZT + ACV. 5. 5. The deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT.
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