Abstract
A 22-year-old Senegalese man with sickle-cell anaemia (SCA; HbS/HbS) was referred to Hepatology department because of cholestasis [AST 82 U/l, ALT 41 U/l, ALP 241 U/l, gGT 135 U/l, bilirubin 8.1 (3.7) mg/dl]; liver function tests were preserved. He was asymptomatic, denied any alcohol or drug intake. Common causes of chronic liver disease were excluded: he was negative for anti-HCV, HBsAg and autoimmune hepatitis markers; copper and iron overload were also excluded. A hard liver was appreciable at the umbilical line, without splenomegaly or decompensation signs. No focal lesions or vascular and biliary disorders were detected at imaging; particularly, there was no evidence of cholelithiasis or choledocholitiasis. Liver Stiffness Measurement (LSM) was 18.5 kPa.
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