Abstract
Cancer is a term given to uncontrolled cell growth, which is the result of accumulation of genetic changes during cell division. It can occur due to both genetic and environmental reasons. One such genetic cause of cancer discovered recently is known as Chromothripsis. It is defined as the fragmentation and rearrangement of chromosomes. Researchers are still trying to find the true mechanism underlying Chromothripsis. Two models have been significantly described; first one is the ‘micronuclei hypothesis’, which occurs as a result of chromosome mis-segregation during Mitosis. Second model is based on the ‘telomere crisis’, which occurs due to faulty telomerase enzyme and cell cycle checkpoint pathway. In this letter, we have tried to give brief information about the mechanisms behind Chromothripsis and their role in causing genome instability leading to cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
