Abstract
A cytogenetic study was carried out for 12 individuals, 7.5 y after exposure to 137Cs in Goiânia (Brazil). The frequencies of translocations were determined by the fluorescence in situ hybridisation (FISH) method, using two cocktails of chromosome probes: #1,6,11 and #3,4,8, and ranges of 0.5 to 9.7 and zero to 4.2 translocations per 100 cells were found, respectively. The mean genomic translocation frequencies were 5.15 ± 1.11, 8.84 ± 1.63 and 22.58 translocations/100 cells for different levels of absorbed doses: <1.0, 1.5-2.0 and 4.6 Gy, respectively, indicating a 10-45 fold increase in relation to the normal frequency. For seven probands, the frequencies of dicentrics were 10 times higher than the control value. The present results are also relevant to a discussion of the reliability and limitations of the analysis of translocations (for a limited number of chromosomes) as a parameter for retrospective biological dosimetry, in cases of human exposure to ionising radiation.
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