Abstract
Phenethyl alcohol (PEA) has been employed as an inhibitor of DNA synthesis in order to elucidate the relationship between the synthesis of DNA in Hfr strains of Escherichia , coli and the transfer of chromosomal markers during conjugation ( Bouck and Adelberg, 1963; and Jacob, Brenner, and Cuzin, 1963). Treick and Konetzka (1964) have shown recently that PEA inhibits the initiation of new cycles of DNA replication in E . coli but permits the completion of those cycles initiated before addition of PEA to the medium. Therefore, cycles of DNA replication can be controlled by the addition, removal, and readdition of PEA to a culture at specific time intervals. The relationship of the DNA replication cycle to the ability of the Hfr to transfer chromosomal markers constitutes the subject of this investigation.
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