Abstract
Phenethyl alcohol (PEA) has been employed as an inhibitor of DNA synthesis in order to elucidate the relationship between the synthesis of DNA in Hfr strains of Escherichia , coli and the transfer of chromosomal markers during conjugation ( Bouck and Adelberg, 1963; and Jacob, Brenner, and Cuzin, 1963). Treick and Konetzka (1964) have shown recently that PEA inhibits the initiation of new cycles of DNA replication in E . coli but permits the completion of those cycles initiated before addition of PEA to the medium. Therefore, cycles of DNA replication can be controlled by the addition, removal, and readdition of PEA to a culture at specific time intervals. The relationship of the DNA replication cycle to the ability of the Hfr to transfer chromosomal markers constitutes the subject of this investigation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
