Abstract
Chromosome Territories Meet a Condensin
Highlights
In human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle
The chromosomes in these cells are amplified by repeated rounds of DNA replication without intervening mitoses, giving rise to polytene chromosomes in which many copies of homologous chromosomes and chromatids are paired along their entire lengths
A previous study from the same group demonstrated that condensin II function is required for the disassembly of polytene chromosomes occurring at this stage [4]
Summary
23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. After the fifth cycle of endoduplication, the pairing of homologous chromatids is disrupted, allowing each set of chromosome arms to occupy a discrete globular territory that is reminiscent of a CT observed in mammalian cells. A previous study from the same group demonstrated that condensin II function is required for the disassembly of polytene chromosomes occurring at this stage [4].
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