Abstract
Chromosome Pairing: A Hidden Treasure No More
Highlights
Many generations of biologists have been intrigued by the myriad structures that eukaryotic chromosomes can adopt and have questioned how their form relates to function [1,2]
Drosophila presents a unique opportunity for identifying molecular regulators that establish, maintain, and antagonize homolog pairing because its homologous chromosomes are almost always paired in somatic cells
Metz described somatic cell homolog pairing in 1916 [10], while Painter first described polytene chromosomes in 1933 [11]—polytene chromosomes are found in some polyploid cells where many copies of homologous chromosomes and chromatids are paired along their lengths
Summary
Many generations of biologists have been intrigued by the myriad structures that eukaryotic chromosomes can adopt and have questioned how their form relates to function [1,2]. Drosophila presents a unique opportunity for identifying molecular regulators that establish, maintain, and antagonize homolog pairing because its homologous chromosomes are almost always paired in somatic cells. Is pairing of homologous sequences in the context of polytene chromosomes similar to somatic or meiotic homolog pairing?
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