Abstract
THE possibility that endogenous deoxyribonuclease might play a part in inducing chromatid breakage was suggested by our experiments describing a high incidence of chromosome breaks and rearrangements in human diploid cell strains after selective damage to lysosomes1. We describe here a similar effect when exogenous deoxyribonuclease is introduced into cells in the presence of hypertonic MgSO4. This is a modification of the method used by Wecker2 in assays of the infectivity of extracted viral nucleic acid.
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