Abstract
Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Highlights
We read with interest the article of Giaretti et al [2] associating specific gene mutations with aneuploidy of sporadic colorectal carcinomas, and the central role of the KRAS2 gene in this process, but we would like to raise some points of discussion on the data presented
The majority of sporadic colorectal cancers present chromosomal instability (CIN), which is believed to be reflected by DNA aneuploidy, and this is thought to be one of the key genomic events in colorectal adenoma to carcinoma progression [3]
Giaretti et al [2] found a significant association of specific mutations on KRAS2 and APC genes, and genomic losses on 1p34–36, with aneuploidy
Summary
We read with interest the article of Giaretti et al [2] associating specific gene mutations with aneuploidy of sporadic colorectal carcinomas, and the central role of the KRAS2 gene in this process, but we would like to raise some points of discussion on the data presented. The majority of sporadic colorectal cancers present chromosomal instability (CIN), which is believed to be reflected by DNA aneuploidy, and this is thought to be one of the key genomic events in colorectal adenoma to carcinoma progression [3]. Despite extensive research efforts in the area, the mechanisms which give rise to this phenotype are still largely unknown [1,4,5,6,7].
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