Abstract
On the basis of literature and proper data the inference was made about the essential role of structural chromosomal (and gene) damages in spontaneous and radiation-induced mutagenesis of mammalian and human cells on HPRT-loci. The evidence of the increasing role of these damages in the mutagenesis after the influence of ionizing radiation with high LET are considered. The consequences of HPRT-gene damages have been examined hypothetically. The heterogeneity of mutant subclones on their cytogenetical properties were revealed experimentally. The data reflect a phenomenon of the reproductive chromosomal instability in many generations of mutant cells. The mutagenesis of mammalian cells is also accompanied by the impairment of chromosome integrity with high probability as a stage of appropriate genome reorganization because of changed vital conditions.
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