Chromosomal Analysis of Couples with Bad Obstetric History

Abstract

Chromosome Abnormalities (CAs) are one of the most important reason of reproductive diseases. The aim of this study was to exhibited the frequency and nature of CAs which is associated with the Bad Obstetric History (BOH) in the south of Turkey. This study was carried out in a total of 895 individuals including 360 couples and 175 single women having BOH and with various incomes were investigated for CAs using blood culture and chromosomal banding technique. A total of 895 individuals with BOH were analyzed, cytogenetically. The chromosomal abnormality was found in 4.4% of the sample studied. The 3.7% of these CAs was structural aberrations, and also numerical CAs was 0.7%. Although in one couple it was the wife and husband who had an abnormal karyotype. Specifically, inversions were the most common karyotypes (1.6%) among the all cases. For example, inversion chromosome 9 was seen among structural anomalies (1.2%). In 6 cases (0.7%), translocations were demonstrated. The others structural CAs (1.5%) were determined with i(9q), fra(Xq28), fra(20%), small(Y), Yqh+ and several CAs variations. Aproximately, 0.7% of individuals with BOH have the numerical CAs and aneuploidies. It was found out that abnormal karyotypes were present in 4.4% of patients with BOH, and associated to female and bad obstetric history. Also, our findings confirm that the structural CAs, such as translocations and inversions were associated with a higher risk of BOH. Therefore, in couples with BOH, chromosomal evaluation can have a diagnostic value.