Abstract
Two chromones and four chromone C-glycosides (1-6), including the new 1, were isolated from the whole plant of Hypericum elodeoides. The structures were characterized by comprehensive analysis of their UV, NMR, ECD and HRESIMS data. The acid hydrolysis of Compounds 1, 2, 4 and 5 demonstrated that the chromone C-glycosides can undergo the Wessely Moser rearrangement. Compound 1 exhibited moderate α-glucosidase inhibitory activity (IC50: 456.26 ± 1.17 µM). Compound 4 could moderately reverse multidrug resistance with an IC50 value of 6.21 ± 0.40 μM (RF: 3.33) in MCF-7/Dox cells.
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