Chromoendoscopy and virtual chromoendoscopy for dysplasia screening in patients with ulcerative colitis (systematic review and meta-analysis)

Abstract

AIM: to compare the diagnostic informativeness of mucosal dye spraying (chromoendoscopy) (CE) and virtual chromoendoscopy (VCE) in detecting dysplasia in patients with a long history ulcerative colitis (UC).MATERIALS AND METHODS: a systematic review and meta-analysis of studies comparing the results of the use of CE and VCE for the diagnosis of colitis-associated dysplasia was performed. The following indicators were evaluated: the frequency of patients with endoscopically detected colitis-associated dysplasia and the frequency of endoscopic diagnosis of colitis-associated dysplasia among the total number of identified lesions. The statistical analysis was carried out using the Review Manager software 5.3RESULTS: the systematic review included 4 studies, analyzing 364 patients in total. In the study groups, there were no statistical differences in patients with endoscopically detected colitis-associated dysplasia and in endoscopic diagnosis of colitis-associated dysplasia among total number of detected colorectal neoplasms (OR = 0.87; 95% CI 0.60–1.27; p = 0.47 and OR = 0.82; 95% CI 0.58–1.18; p = 0.29).CONCLUSION: meta-analysis could not demonstrate a significant difference between CE and VCE. However, additional studies are needed to recognize the role of VCE in the differentiation of neoplastic and non-neoplastic lesions in patients with UC