Chromatographic Retention and Enantioseparation of Amino Acid Derivatives on Aminated β-Cyclodextrin as Functions of the Hydrophobicity of Adsorbates

Abstract

The retention and separation of optical isomers of amino acid derivatives on aminated β-cyclodextrin was studied. The pH dependence of the distribution coefficients of these derivatives in the octanol–water system was found. It was demonstrated that the capacity factors and the enantioselectivity of the separation of amino acid derivatives depend on the hydrophobicity of the studied compounds.