Comparison of various non-polar stationary phases used for assessing lipophilicity

Abstract

Two non-polar stationary phases, i.e., a novel octadecylpolyvinyl ( ODP) packing and a poly(styrene-divinylbenzene) ( PLRP-S) gel, were compared with a standard phase (octadecylsilane, ODS) for their usefulness in determining lipophilicity. Various monosubstituted benzenes and neuroleptic drugs were used as solutes. The usefulness of the polystyrene divinylbenzene phase was limited by physical problems, long retention times and capacity factors which did not appear to express the same partitioning behaviour as in an octanol-water system. In contrast, the ODP phase proved very interesting. Like the ODS phase, it showed high selectivity and fast elution, and yielded retention data which reflect a partitioning behaviour comparable to that seen in an octanol-water system. It also proved superior to the ODS phase in that it did not require the addition of a masking agent.