Chromato-mas-spectroscopic study of the chemical composition of growing in ukraine Tanacetum corymbosum (L.) Sch. Bip. populations

Abstract

The aim of the work was the chromato-mas-spectroscopic studyof the chemical composition of Tanacetum corymbosum (L.) Sch. Bip. and the identification of further prospects for the use of raw materials of this plant in medical and pharmaceutical practice.Materials and methods. The object of the study was the grass of Tanacetum corymbosum (L.) Sch. Bip., which was collected in Zaporizhzhia in July 2019. The method of high-performance gas chromatography on the device Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometry detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) was used to determine the chemical composition of Tanacetum corymbosum (L.) Sch. Bip. The NIST14 mass spectrum library was used to identify the components.Results. There were 42 components, which were contained in the grass of Tanacetum corymbosum (L.) Sch. Bip. (2 are isomers). They belong to different classes of biologically active substances. There were: terpenoids (39.53 %), heterocyclic compounds (34.75 %), fatty acids and their derivatives (9.78 %), hydrocarbons (7.23 %), alcohols (5.61 %), aldehydes and ketones (0.74 %).2H-Cyclohepta[b]furan-2-one,3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxobutyl)-, [3aR-(3a.alpha.,7.beta.,8a.alpha.)]- was constituted the main part among all found compounds – 24.46 %, (+)-2-bornanone (11.85 %) and bicyclo[3.1.1]hept-2-en-6-ol, 2,7,7-trimethyl-, acetate, [1S-(1.alpha.,5.alpha.,6.beta.)]- (16.27 %) are next.Also, n-tetracosanol-1 and 4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl) -5-hydroxy-3,6,7-trimethoxy- were presented in quantity 4.78 % and 4.48 % respectively.Considering all of the above and information, which was obtained from publications of Ukrainian and foreign authors, further prospects for the use of Tanacetum corymbosum (L.) Sch. Bip. in medical and pharmaceutical practice can be considered.Conclusions. The chemical composition of grass of Tanacetum corymbosum (L.) Sch. Bip. was established by method of gas chromatography with mass spectrometry detector. 42 components were identified (2 in the isomeric state). They belong to different groups of biologically active substances: terpenoids, heterocyclic compounds, fatty acids and their derivatives, hydrocarbons, alcohols, aldehydes and ketones. Considering the biological properties of the main active ingredients, the raw materials of Tanacetum corymbosum (L.) Sch. Bip. can be considered as a promising source of antioxidant, antimicrobial and anti-inflammatory drugs.