Abstract
Alternative chromatin structures of the chicken lysozyme gene domain characterize the steroid-inducible state of the gene in oviduct cells and the constitutive-expressing, steroid-independent state in mature macrophages. Using DNA transfection studies and the method for mapping DNase — hypersensitive chromatin sites, we have identified a number of cis-acting, positive, negative, and inducible DNA elements in the 5′-flanking region which have to work together to control the cell- and stage-specific transcriptional activation of the gene.
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