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https://doi.org/10.1101/2024.09.19.613927
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Cite Publication Date: Sep 20, 2024 | |
 Citations: 1 |
BRG1 recruits HTT and NHEJ components to transcriptionally active DSBs.HTT joins BRG1 and PNKP to efficiently repair transcription related DSBs in brain.Mutant HTT impairs the functional integrity of TC-NHEJ complex for DSB repair.HTT expression improves DSB repair, genome integrity and phenotypes in HD flies.
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