Abstract
In vitro acetylation of chromosomal proteins and RNA synthesis, and their modulation by spermine were studied using slices of cerebral cortex of 3 – 30 day old developing male rats. The degree of acetylation of both histones and nonhistone chromosomal (NHC) proteins, and RNA synthesis are high at day 3 and decrease rapidly as development progresses. Spermine stimulates acetylation of histones and NHC proteins. It also stimulates incorporation of 3H-Uridine both into nuclear and cytoplasmic RNAs. These stimulatory effects decrease rapidly up to day 9 and then decrease more slowly. Such chemical and functional changes in chromatin may be necessary for the terminal differentiation of neurons, and contribute to differential gene expression during development.
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