Abstract
In vitro acetylation of chromosomal proteins and RNA synthesis, and their modulation by spermine were studied using slices of cerebral cortex of 3 – 30 day old developing male rats. The degree of acetylation of both histones and nonhistone chromosomal (NHC) proteins, and RNA synthesis are high at day 3 and decrease rapidly as development progresses. Spermine stimulates acetylation of histones and NHC proteins. It also stimulates incorporation of 3H-Uridine both into nuclear and cytoplasmic RNAs. These stimulatory effects decrease rapidly up to day 9 and then decrease more slowly. Such chemical and functional changes in chromatin may be necessary for the terminal differentiation of neurons, and contribute to differential gene expression during development.
Published Version
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