Abstract
AbstractQuantified pupil responses to colored light stimuli is a non‐invasive means to monitor melanopsin function as well as rod and cone activity. Understanding the trivariate contributions to the pupil light reflex has led to renewed interest in using the pupil response to monitor a variety of diseases. The characteristic pupillographic feature of intrinsic, melanopsin‐mediated ganglion cell activity is persistent contraction after light offset. This post‐illumination response is abnormal in patients with glaucoma. In patients with retinal degenerative disease, the retinal sensitivity to blue light as measured by pupillometry is reduced. This correlates with loss of rod function but also hints at reduced melanopsin activity. Clinical examples showing pupil response to red and blue light in patients with neuroretinal visual loss will be discussed. Commercial interest
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