Abstract
An age related decrease in central cholinergic neurons that is particularly severe in patients with senile dementia may underlie the cognitive impairment of the aged. This possibility is supported by pharmacological studies demonstrating a decrement in memory processes following administration of anticholinergic drugs and an improvement in some aspects of memory function following the administration of cholinomimetics. The ability of drugs that increase cholinergic activity to improve cognitive processes in the elderly and patients with senile dementia will probably depend on the degree of cholinergic receptor degeneration in these patients.
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