Abstract
A simplified procedure for preparing the cholinergic neurotoxin 1-ethyl-1-(2-hydroxyethyl) aziridinium ion (AF64A) is reported that employs stoichiometric base. When injected intracerebroventricularly into rats, stoichiometrically prepared AF64A causes impairments in spatial working memory in a water-maze task. The behavioral changes are paralleled by deficits in hippocampal choline acetyltransferase activity, a neurochemical marker of the resulting cholinergic dysfunction.
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