Abstract
Metabolism of the insect growth regulator methorpene by a steer produced labeled cholesterol, cholic acid, and deoxycholic acid. Cholesterol and deoxycholic acid were degraded chemically by Kuhn-Roth and Barbier-Wieland oxidations to show catabolism of [5- 14C] methoprene to [2- 14C] acetate. Unless radioactive residues are rigorously characterized as primary metabolites rather than natural products, misinterpretations will occur when assessing metabolic pathways for extremely biodegradable compounds such as methoprene.
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