Abstract
A factorial experiment involving 90 adult male New Zealand white rabbits was carried out to explore the effect of serum cholesterol levels and duration of exposure on the cholesterol contents of 15 different tissues. Individual serum cholesterol levels were maintained constant at fixed levels ranging from 29 to 2632 mg/100 ml among the groups for periods of 30, 60, and 90 days before being sacrificed. The relationships among these three variables could be expressed by various forms of regression equations. Cholesterol contents of pancreas and testis were proportional to serum cholesterol level only, while those of colon, spleen, heart, and kidney were related independently to serum cholesterol level and exposure time. Interaction of these two factors played the major role in determination of the cholesterol content of aorta and adipose tissue and to some extent the lung. A quadratic equation or curvilinear curve was found in the other five tissues. Cholesterol content of the skin was primarily affected by the interaction of serum cholesterol level and exposure time, that of adrenal and liver was determined by these two factors independently, whereas that of small intestine and muscle was affected by both of these factors and their interaction. Brain was the only tissue that did not show a change of its cholesterol content throughout the experiment.
Published Version
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