Abstract
Recently, in the clinical practice of treating hepatobiliary diseases, significant progress has been made in understanding the molecular basis of bile formation and cholestasis pathophysiology. This article briefly summarizes the modern concepts of bile formation and cholestasis. The goals of drug therapy for cholestasis have been determined, which help to understand existing methods of treating cholestasis and contribute to the development of new agents for cholestatic liver diseases.
Highlights
In the clinical practice of treating hepatobiliary diseases, significant progress has been made in understanding the molecular basis of bile formation and cholestasis pathophysiology
This article briefly summarizes the modern concepts of bile formation and cholestasis
(In Russ.) Диагностика и тактика ведения первичного билиарного холангита: клинические рекомендации EASL Европейская ассоциация по изучению печени (EASL)
Summary
Экзотоксины Эндотоксины Снижение скорости протока желчи Состояния, изменяющие концентрацию желчи (сепсис, гиперэстрогенные состояния, беременность и хроническая сердечная недостаточность). Обструкция транспорта желчи (внутрипеченочная и внепеченочная, внешнее сдавливание желчного протока). Нарушение потока желчи во внутрилобулярных протоках (кистозный фиброз, метастазы, саркоидоз) или в пределах больших внутрипеченочных протоков
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