Abstract
The neuroleptic phenothiazine derivative chlorpromazine (CPZ) at high concentration (1 x 10(-5) M) decreased either the phasic or tonic contraction in response to carbachol and the carbachol-induced increase in [Ca2+]i in both phases in ileal muscle. In contrast, CPZ at low concentrations (8 x 10(-7) - 5 x 10(-6) M) decreased only the phasic contraction and potentiated the tonic contraction induced by carbachol. However, CPZ at these concentrations dose-dependently decreased the carbachol-induced increase in [Ca2+]i in both phases. These results suggested that CPZ dose-dependently decreased the initial phasic contraction in response to carbachol by inhibition of Ca2+ release from the intracellular storage sites. CPZ at low concentrations appears to increase Ca2+ sensitivity to contractile proteins in the carbachol-induced tonic phase. CPZ dose-dependently reduced the 60 mM K(+)-induced phasic and tonic responses and a concomitant decrease in [Ca2+]i in ileal muscle.
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