Chlorotic Anemia with Achlorhydria, Splenomegaly, and Small Corpuscular Diameters

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Article1 February 1931Chlorotic Anemia with Achlorhydria, Splenomegaly, and Small Corpuscular DiametersWILLIAM S. MCCANN, M. D., JANE DYE, A. B.WILLIAM S. MCCANN, M. D.Search for more papers by this author, JANE DYE, A. B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-8-918 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe brilliant specific results of liver therapy in pernicious anemia announced by Minot and Murphy4, following upon the demonstration by Whipple and Robscheit-Robbins8 of the importance of liver feeding in the chronic anemias of dogs, induced by repeated bleeding, have led to a widespread attempt to treat all anemias with liver. In many of the so-called seccondary anemias the response to liver therapy is only partially successful and in others entirely disappointing, when compared with the results in pernicious anemia.It is the object of this paper to present the clinical features of a group of anemic patients, all of...Bibliography1 FABERGRAM KHC: Relations between Gastric Achylia and Simple and Pernicious Anemia. Arch. Int. Med., 34:658. 1924. CrossrefGoogle Scholar2 ISAACSDANIELIAN RAC: Maintenance of Leucocyte Level and Changes During Irradiation. Am. J. Med. Sci., 174:70. 1927. CrossrefGoogle Scholar3 KAZNELSONREIMANNWEINER PFW: Achylische Chloranaemie. Klin. Wchnschr., 8:1071, June 4, 1929. CrossrefGoogle Scholar4 MINOTMURPHY GRWP: Treatment of Pernicious Anemia by a Special Diet. J.A.M.A., 87:470, 1926. CrossrefGoogle Scholar5 MINOT GR: Oxford Medicine. Vol. II, p. 600-603. Oxford Univ. Press. New York, 1920. Google Scholar6 PEARL R. Introduction to Medical Biometry and Statistics. W. B. Saunders, Philadelphia, 1923 pp. 264-293. Google Scholar7 PRICE-JONES C: The Diurnal Variation in the Sizes of Red Blood Cells. J. Path. Bact., 23:371, 1920. Anisocytosis with Special Reference to Pernicious Anemia. Guy's Hospital Reports, 74:10, 1924. CrossrefGoogle Scholar8 ROBSCHEIT-ROBBINSWHIPPLE FSGH: Blood Regeneration in Severe Anemia, II. Favorable influence of Liver, Heart, and Skeletal Muscle in Diet. Am. J. Physiol., 72:408, 1925. CrossrefGoogle Scholar9 ROMBERG E: Bemerkungen über Chlorose und ihre Behandlung. Berl. Klin. Wchnschr., 1897:559, Nos. 25-26. Google Scholar10 SHERMAN HC: Iron in Food and Its Function in Nutrition. Bull. 185. U.S. Dep't. Agric., Washington, D. C., Gov't. Print. Office. 1907. Google Scholar11 STURGISISAACS CCR: Dessicated Stomach in the Treatment of Pernicious Anemia. J.A.M.A., 93:747, 1929. CrossrefGoogle Scholar12 VANSLYKENEILL DDJM: The Determination of Gases in Blood and Other Solutions by Vacuum Extraction and Manometric Measurement. I. J. Biol. Chem. 61:523, 1924. CrossrefGoogle Scholar13 WADDELLSTEENBOCKELVEHIEMHART JHCAEB: Iron in Nutrition. J. Biol. Chem., 77:769, 1928. ibid. 77:777, 1928. ibid. 77:797, 1928. CrossrefGoogle Scholar14 WADDELLSTEENBOCKHART JHEB: Iron in Nutrition, IX. J. Biol. Chem., 83:251, 1929. ibid. 84:115, 1929. CrossrefGoogle Scholar15 WHIPPLEROBSCHEIT-ROBBINSWALDEN GHFSGB: Blood Regeneration in Severe Anemia, XXI. A Liver Fraction Potent in Anemia Due to Hemorrhage. Am. J. Med. Sci., 179: 628, 1930. CrossrefGoogle Scholar16 WHIPPLEROBSCHEIT-ROBBINS GHFS: Blood Regeneration in Severe Anemia, XVII. Influence of Manganese, Zinc, Copper, Aluminum, Iodine and Phosphates. Am. J. Physiol., 92:378, 1930. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*From the Department of Medicine of the University of Rochester, School of Medicine and Dentistry, and the Medical Clinic of the Strong Memorial Hospital, Rochester, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErbpathologie des Blutes und der blutbildenden OrganeObservations on the morphology of the erythrocytes in mediterranean disease—ThalassemiaDisturbances of menstruation due to simple achlorhydric anemia 1 February 1931Volume 4, Issue 8Page: 918-930KeywordsAchlorhydriaAnemiaDentistryHemorrhageHospital medicineLiverPernicious anemiaSplenomegaly Issue Published: 1 February 1931 PDF downloadLoading ...