Abstract
This study's main goals are to give an overview of chitosan-based nanoparticles used in a variety of non-parenteral applications and to call attention to new research on mucoadhesive and sustained release chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer that has been certified for use in wound dressings and is suitable for inclusion in human diets. For a variety of drug delivery methods, chitosan has been employed as a drug carrier in polymeric nanoparticles. Chitosan is a polymer with numerous possible uses since it has chemical functional groups that can be altered to serve particular purposes. The positive surface charges and mucoadhesive qualities of nanoparticles (np) made of chitosan and chitosan derivatives enable them to stick to mucous membranes and gradually release the therapeutic payload. This review will include examples of non-parenteral drug delivery techniques for treating eye infections, cancer, gastrointestinal disorders, pulmonary disorders, and cancer. Both in vitro and a few in vivo investigations show that chitosan has a low level of toxicity. This review looks at recent investigations on the characteristics, modifications, toxicity, pharmacokinetics, and preclinical trials of nanoparticles (np) made of chitosan for non-parenteral drug delivery.
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