Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating Network For Controlled Release of Drugs

Christian Gonzales,Takahiko Nakaoki,Soma Chakraborty,Ivy Marie C Andalis,Mari Kaira O Leal,Modesto T Chua

doi:10.26534/kimika.v26i1.1-9

Abstract

Semi-interpenetrating polymer networks (semi-IPNs) composed of polyacrylic acid (PAA), and chitosan or N-(3-chloro-2-hydroxypropyl)trimethylammonium chloride (Quat-188) modified chitosan were synthesized. To fabricate the semi-IPN, acrylic acid (AA) was polymerized and crosslinked in the presence of unmodified and Quat-188 modified chitosan. The wet strength of the semi-IPNs improved with the increase in molecular weight of chitosan, chitosan to PAA ratio and by Quat-188 modification. Both modified and unmodified semi-IPNs swelled in buffer solutions. Swelling was pH dependent. The mode of encapsulation and release of two different types of drugs from these semi IPNs was studied. Effects of various parameters on encapsulation and release of AgNO3 and mafenide acetate from these semi-IPNs were investigated. The semi-IPN hydrogel encapsulated 10 mmol/L AgNO3 (100% of added drug) in 5min and released 4% of it in 2h. In case of mafenide acetate, pH dependent encapsulation and controlled release was observed. It was observed that drug-semi IPN interaction strongly influences the encapsulation and release behavior. Freezable water associated with the hydrogels also played an important role for the encapsulation and release of drug.

Highlights

Chitosan, a derivative of chitin, due to its availability, biodegradability, and biocompatibility, has been utilized for numerous pharmaceutical and biomedical applications that includes controlled drug delivery (Park et al 2010; Quiñones et al 2011; Li et al 2011), scaffolding (Li et al 2010; Wu et al 2011; Jaykumar et al 2011) and as sensor (Odaci et al, 2008; Njagi et al 2010).Some of the above mentioned applications use chitosan in semi-IPN form
Chitosan was modified with Quat-188 to enhance its cationic nature for efficient interaction with polyanionic polyacrylic acid
Semi IPN network of chitosan and polyacrylic acid (PAA) was synthesized in one step

Summary

Introduction

A derivative of chitin, due to its availability, biodegradability, and biocompatibility, has been utilized for numerous pharmaceutical and biomedical applications that includes controlled drug delivery (Park et al 2010; Quiñones et al 2011; Li et al 2011), scaffolding (Li et al 2010; Wu et al 2011; Jaykumar et al 2011) and as sensor (Odaci et al, 2008; Njagi et al 2010).Some of the above mentioned applications use chitosan in semi-IPN form. Our project aimed to fabricate of chitosan and chitosan N-(2-hydroxypropyl)trimethylammonium chloride (modified chitosan) PAA semi IPN that can be and to study the impact of swelling, drug-polymer interaction and the size of the drug on the encapsulation and release behavior from Chitosan PAA matrix. The amount of mafenide acetate released was quantified from the Chitosan and Quat-188 Modified Chitosan Poly(acrylic acid) Semi-Interpenetrating...

Results

Conclusion