Abstract
Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.
Highlights
Wounds are injuries on the skin [1]
The results demonstrated that the chitosan-based hydrogels arehydrogels potential are potential scaffolds for burn wound management scaffolds for burn wound management
The biopolymer hydrogels that are based on cellulose and chitosan demonstrated excellent features for the management of wounds
Summary
Wounds are injuries on the skin [1]. They are classified as acute and chronic wounds. Wound dressings are mostly developed from biopolymers and synthetic polymers. The natural polymers that are commonly utilized include chitosan, cellulose, fibrin, elastin, hyaluronic acid, dextran, elastin, alginate, collagen, and gelatin [6] These polymers possess interesting properties suitable for wound management such as good biocompatibility, non-toxicity, biodegradability, readily availability, and non-immunogenicity [7]. These polymers are usually cross-linked with synthetic polymers because. The synthetic polymers include poly(vinyl pyrrolidone) (PVP), poly(ethylene oxide)(PEO)/poly(ethylene glycol) (PEG), of their poor mechanical properties. In the design of an ideal wound dressing, factors that are usually considered are their poly(lactic-co-glycolic acid) (PLGA) and polylactide (PLA)) [6,8].
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