Abstract
The use of mixtures of sulfated β-cyclodextrins and native α-cyclodextrin as chiral additives in capillary electrophoresis was evaluated for the chiral resolution of neutral, cyclic and bicyclic monoterpenes, including α-pinene, β-pinene, camphene and limonene. Binding properties of sulfated β-cyclodextrins towards these monoterpenes were studied. It was found that there was no enantioresolution of these terpenoids over the concentration range studied. However, the addition of α-cyclodextrin to the running electrolyte in addition to 6.5 m M sulfated β-cyclodextrins, imparted differences in the mobilities of the terpenoid enantiomers and resulted in remarkable enantiomeric separations of α-pinene ( R s = 25), β-pinene ( R s = 12), camphene ( R s = 12) and limonene ( R s = 4). The role of both α-cyclodextrin and sulfated β-cyclodextrins in these separations is discussed.
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