Abstract
The concept of transferring the chirality from small molecules to nanomaterials has aroused great interest. On the other hand, photodynamic inactivation (PDI) is a promising technology for food preservation, due to its high antibacterial ability and none microbial resistance. Herein, chiral boron dipyrromethenes (denoted as L/D-BDP) were prepared and their nano-formulations (L/D-BDP NPs) were fabricated. L/D-BDP NPs significantly amplified the chirality of L/D-BDP, leading to essentially enhanced antibacterial activity. L/D-BDP NPs could eradicate Gram-positive bacteria (S. aureus), with L-BDP NPs showing more significant antimicrobial activity than D-BDP NPs. Different content (0, 0.5%, 1% and 2%) of L/D-BDP NPs were doped with chitosan and glycerol to prepare antibacterial films (CG, 0.5%L/DCG, 1%L/DCG and 2%L/DCG, respectively). Among which, 2%LCG film has the most efficacious antimicrobial activity. In the 8-day cherry preservation experiment, 2%LCG film irradiated with green light for 8 min could effectively inhibit cherries mildew, delay the loss of vitamin C and total polyphenol content, and significantly prolong the storage period of cherries at room temperature. This study presents a new approach for constructing highly efficient chiral antimicrobial nano-agents, which is conducive to develop chiral functional nanomaterials that tailored for specific biological and medical purposes.
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