Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper‐Catalyzed Asymmetric Borylation of α,β‐Unsaturated Ketones

Abstract

AbstractA novel chiral bipyridine ligand bearing a flexible side chain with a molecular recognition site enables precise stereocontrol through the cooperative action of metal center and hydrogen bonds. This new chiral ligand was applied to the copper‐catalyzed asymmetric borylation of α,β‐unsaturated carbonyl compounds. The reaction afforded the corresponding borylated products in good yields with high enantioselectivities. Preliminary studies of the functional group‐selective transformation revealed that the newly designed chiral bipyridine ligand has the potential to control chemo‐ and site selectivity in addition to stereoselectivity.