Abstract
Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes brain protein synthesis, enhances dopamine function, regulates brain hormones, and improves microcirculation in central nervous system that might improve, repair and rehabilitation from the stroke and brain injury. Specific Chinese herbs and their components, such as Acanthopanax, Angelica, could maintain the survival of neural stem cells, and Rhodiola, Ganoderma spore Polygala, Tetramethylpyrazine, Gardenia, Astragaloside and Ginsenoside Rg1 promoted proliferation of neural stem cells, and Rhodiola, Astragaloside promoted differentiation of neural stem cell into neuron and glia in vivo. Astragalus, Safflower, Musk, Baicalin, Geniposide, Ginkgolide B, Cili polysaccharide, Salidroside, Astragaloside, Antler polypeptides, Ginsenoside Rg1, Panax notoginseng saponins promoted proliferation and differentiation of neural stem cells in vitro. Salvia, Astragalus, Ginsenoside Rg1, P. notoginseng saponins, Musk polypeptide, Muscone and Ginkgolide B promoted neural-directed differentiation of MSCs into nerve cells. These findings are encouraging further research into the Chinese herbs for developing drugs in treating patients of stroke and brain injury.
Highlights
Neural stem cells (NSC) in the central nervous system are capable of self-replication, proliferation, migration and differentiation [1]
This discovery contravened the dogma [3] that new neurons involving in the repair of nerve tissue cannot be produced after neuronal degeneration and necrosis in the central nervous system (CNS)
This study aims to focus on the efficacy and roles of Chinese medicine (CM) in the survival, self-proliferation, directed migration, and differentiation of NSCs
Summary
Neural stem cells (NSC) in the central nervous system are capable of self-replication, proliferation, migration and differentiation [1]. Astragalus saponin induced the differentiation of NSCs in the SVZ and cortex in embryonic mouse brains into neurons This induction showed no concentration effect [55,56]. Rg1 promoted proliferation of embryonic rat SVZ NSCs and protected them against glutamateinduced damage, and this effect was relevant for increasing the percentage of STAT3-positive cells [21,52]. Limitations and further studies Current research is limited to the effects of a selection of Chinese herbs and their active components on neural stem cell proliferation and differentiation. The mechanisms of their actions are largely unknown.
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