Abstract
Atherothrombosis, which directly threatens people's health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the blood stasis syndrome and promoting blood circulation and removing blood stasis is the most active field of research of integration of traditional and western medicine in China. Blood-stasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting blood circulation and removing blood stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis and is to be deeply discussed in further research.
Highlights
Cardiovascular and cerebrovascular events have become the major killer of people’s health and life all over the world
If pretreated by RESV, protein kinase C (PKC) translocation to the membrane was partially inhibited in the platelets activated by ADP. These results suggested that RESV inhibited the PKC-mediated signal transduction pathway in platelets, and it might act as an inhibitor on PKC activity in platelets and serve as a novel antithrombotic agent
Studies show that influence of TXA2/PGI2 has been closely related to antiplatelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis (PBCRBS), such as Total saponins of paeonia [59] can reduce the ADP-induced platelet maximum aggregation rate and plasma TXB2 concentration, increase the plasma 6-keto-PGF1α concentration, which means it can promote the release of PGI2, inhibit the produce of TXA2, improve the balance of TXA2/PGI2, and reach the aim of antithrombotic therapy
Summary
Cardiovascular and cerebrovascular events have become the major killer of people’s health and life all over the world. Studies show that influence of TXA2/PGI2 has been closely related to antiplatelet mechanism of Chinese herb and formulas for PBCRBS, such as Total saponins of paeonia [59] can reduce the ADP-induced platelet maximum aggregation rate and plasma TXB2 concentration, increase the plasma 6-keto-PGF1α concentration, which means it can promote the release of PGI2, inhibit the produce of TXA2, improve the balance of TXA2/PGI2, and reach the aim of antithrombotic therapy. Compound Danshen dripping pills [67] and pseudoginseng [68] have the same mechanism of antiplatelet
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