Abstract
Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2. However, some patients may be “resistant” to its effect. The resistance has close association with adverse cardiovascular outcomes and increased mortality, so that resolving the problem of aspirin resistance (AR) is widely concerned. By studying the correlation between AR and blood stasis syndrome (BSS), it is demonstrated that BSS may be one of the pathogenesis of AR in traditional Chinese medicine. Chinese herb and formulas definitely possess the advantage of whole body regulation by many ways and many targets. It is a new direction for treatment of AR to combine TCM and modern medicine to study the mechanism and prevention of AR.
Highlights
Despite recent medical advances, cardiovascular diseases (CVDs) remain the primary cause of morbidity and mortality throughout the world [1]
Evidence of a number of large-scale clinical trials demonstrated that aspirin is a cornerstone in the primary and secondary prevention of CVDs [3, 4]
Recent study showed that aspirin inhibits COX-1 approximately 170-fold more potently than COX-2 [8]
Summary
Cardiovascular diseases (CVDs) remain the primary cause of morbidity and mortality throughout the world [1]. Evidence of a number of large-scale clinical trials demonstrated that aspirin is a cornerstone in the primary and secondary prevention of CVDs [3, 4] It is widely used in the medical management of acute coronary syndromes, in the prophylaxis of patients undergoing percutaneous angioplasty or vascular grafting and in long-term prevention of cardiovascular and cerebrovascular events [5]. AR is widely manifested and associated with increased cardiovascular risk in aspirin-treated patients This side effect can significantly influence the clinical effect. Aspirin resistance is a multifactorial phenomenon, so strategies of treatment should be directed to a number of COX-1 dependent and other independent factors, such as increasing patient compliance, increasing dose of levels, combining with other antiplatelet drugs, or applicating other kinds of drugs as alternatives. We can seek solution from traditional Chinese medicine (TCM)
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