Childhood cardiovascular risk factors and adult cardiovascular events

Abstract

Brief summary: This prospective cohort study leveraged data from the International Childhood Cardiovascular Cohorts (i3C) Consortium, including 42 324 participants at baseline and followed-up over a mean of 35 years, in order to investigate associations between cardiovascular risk factors (CVRF, including body-mass index, systolic blood pressure, total cholesterol levels, triglycerides, and smoking) in childhood (mean age 11.8 years) with fatal and non-fatal cardiovascular events in adulthood (mean age 47 years). They showed that increases in each individual CVRF in childhood, and a combined-CVRF risk score, were associated with higher risks of fatal and non-fatal cardiovascular disease events in adults, robust to adjustment for adult CVRF levels.