Abstract
1. (1) Acute, always fata, Trypanosoma gambiense and Trypanosoma rhodesiense infections in mice ( Mus musculus) were cured with adequate dosages of captostibone [sodium 2-(carboxy-methylmercapto) benzene stibonate]. 2. (2) Administration of 150 to 200 mg./kg. of captostibone sodium daily for 4 days intraperitoneally produced from 80 to 100 per cent. curative effects in mice infected with T. gambiense or T. rhodesiense; with dosages ranging from 75 to 125 mg./kg. daily for 4 days, percentages of cures were less. 3. (3) All mice that survived and remained free of trypanosomes were discarded as cured 60 to 212 days following cessation of therapy. 4. (4) One hundred and fifty-five untreated control mice, 70 infected with T. gambiense and 85 infected with T. rhodesiense, all invariably died of acute trypanosomiasis in from 3 to 5 days.
Published Version
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