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CancerVolume 30, Issue 6 p. 1480-1487 ArticleFree Access Chemotherapy of acute lymphocytic leukemia of childhood James F. Holland MD, James F. Holland MD Acute Leukemia Group B Operations Office, 651 Elm St., Buffalo, N.Y. 14203Search for more papers by this authorOliver Glidewell MA, Oliver Glidewell MA Acute Leukemia Group B Operations Office, 651 Elm St., Buffalo, N.Y. 14203Search for more papers by this author James F. Holland MD, James F. Holland MD Acute Leukemia Group B Operations Office, 651 Elm St., Buffalo, N.Y. 14203Search for more papers by this authorOliver Glidewell MA, Oliver Glidewell MA Acute Leukemia Group B Operations Office, 651 Elm St., Buffalo, N.Y. 14203Search for more papers by this author First published: December 1972 https://doi.org/10.1002/1097-0142(197212)30:6<1480::AID-CNCR2820300611>3.0.CO;2-3Citations: 84AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Aur, R. J. A., et al.: Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood 37: 272– 281, 1971. 2 Bernard, J., and Boiron, M.: Current status: Treatment of acute leukemia. Semin. Hematol. 7: 427– 440, 1970. 3 Burgert, E. O. Jr., et al.: Acute lymphocytic leukemia in children. Maintenance therapy with methotrexate administered intermittently. JAMA 207: 923– 928, 1969. 4 Chevalier, L., and Glidewell, O. J.: Schedule of 6-MP and effect of inducer drugs on remission maintenance of acute leukemia. Proc. Am. Assoc. Cancer Res. 8: 10, 1967. 5 Farber, S., Diamond, L. K., Mercer, R. D., Sylvester, R. F. Jr., and Wolff, J. A.: Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). N. Engl. J. Med. 238: 787, 1948. 6 Frei, E. III., et al.: Studies of sequential and combination antimetabolite therapy of acute leukemia: 6-mercaptopurine and methotrexate. (From the Acute Leukemia Group R.) Blood 18: 431– 454, 1961. 7 Frei, E., et al.: A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood 13: 1126– 1148, 1958. 8 Frei, E. III., et al.: The effectiveness of combinations of anti-leukemic agents in inducing and maintaining remission in children with acute leukemia. Blood 26: 642– 656, 1965. 9 Freireich, E. J., et al.: The effect of 6-mercaptopurine on the duration of steroid induced remission in acute leukemia: A model for evaluation of other potentially useful therapy. Blood 21: 699– 716, 1963. 10 Goldin, A., Mantel, N., Greenhouse, S. W., Venditti, J. M., and Humphreys, S. R.: Factors influencing the specificity of action of an antileukemic agent (aminopterin). Time of treatment and dosage schedule. Cancer Res. 14: 311– 314, 1954. 11 Holland, J. F.: Clinical studies of unmaintained remissions in acute lymphocytic leukemia. In The Proliferation and Spread of Ncoplastic Cells, E. Frei, Ed. Baltimore, Williams and Wilkins, 1968; pp. 453– 462. 12 Holland, J. F.: Intensive high dose treatment of children in complete remission of acute lymphocytic leukemia. In Treatment of Burkitt's Tumor. Proceedings of a Conference Organized by the Chemotherapy Panel of the International Union Against Cancer. Heidelberg, Springer-Verlag 1967; pp. 163– 169. 13 Holland, J. F.: Progress in the Treatment of Acute Leukemia, 1966. In Perspectives in Leukemia. New York, Grune and Stratton, 1968; pp. 217– 240. 14 Holland, J. F.: Who should treat acute leukemia? JAMA 209: 1511– 1513, 1969. 15 Holland, J. F., and Glidewell, O. J.: Progress in the chemotherapy of acute leukemia. In The Nature of Leukemia, P. C. Vincent, Ed. Sydney, Australia, V. C. N. Blight, 1972; pp. 257– 271. 16 Holland, J. F., and Glidewell, O. J.: Survival expectancy in acute lymphocytic leukemia. N. Engl. J. Med. 287: 769– 777, 1972. 17 Law, L. W.: Effects of combinations of antileukemic agents on an acute lymphocytic leukemia in mice. Cancer Res. 13: 871– 878, 1952. 18 Selawry, O. S., et al.: New treatment schedule with improved survival in childhood leukemia. Intermittent parenteral vs. daily oral administration of methotrexate for maintenance of induced remission. JAMA 194: 76– 81, 1965. 19 Skipper, H. E., Schabel, F. M. Jr., and Wilcox, W. S.: Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with “curability” of experimental leukemia. Cancer Chemother. Rep. 35: 1– 111, 1964. Citing Literature Volume30, Issue6December 1972Pages 1480-1487 ReferencesRelatedInformation

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